我院小儿肿瘤科住院患儿超说明书用药分析

Off-Label Use of Inpatients in Pediatric Oncology Department

目的:调查我院小儿肿瘤科住院患儿超说明书用药情况,为临床合理用药提供参考。方法:采用回顾性研究方法,随机抽取我院小儿肿瘤科2014年9月至2015年8月的住院患儿300例,依据药品说明书和相关文献,分析超说明书用药情况。结果:300例患儿共计医嘱6 259条,涉及药品228种。300例患儿中,超说明书用药的患儿188例(62.67%),超说明书用药医嘱1 007条(16.09%),超说明书用药涉及药品49种。结论:我院小儿肿瘤科普遍存在超说明书用药情况,给医疗纠纷事件的发生埋下了隐患,呼吁有关部门采取有效措施进行监管,关注儿童用药,杜绝不必要的超说明书用药。

Objective： To retrospective analyze the situation of off-label use on pediatric oncology department inpatients, to provide basis of rational drug usage to pediatric oncology department. Methods： We randomly selected 300 medical records in pediatric oncology department from September, 2014 to August, 2015. According to the drug instructions and related literature, analyzed the off-label use. Results： There were 6,259 medical orders and 228 kinds of drugs. One hundred and eighty-eight inpatients were involved with off-label use in total 300 inpafients and the rate was 62. 67%. There were 1,007 off-label use of medical orders and the off-label use rate was 16. 09%. There were 49 kinds of drugs involved in off-label use. Conclusion： The situation of off-label use is general in pediatric oneology department, which become the hidden danger of medical dispute. We should carry out relevant solutions to control and stop the unnecessary off-label use.