匹伐他汀钙治疗老年脑梗死患者颈动脉粥样硬化斑块的疗效及其对患者血脂水平的影响

Clinical effect of pitavastatin calcium in treatment of gerontal patients with acute cerebral infarction combined with carotid atherosclerosis and its impact of blood lipid levels

目的探讨匹伐他汀钙治疗老年急性脑梗死患者颈动脉粥样硬化斑块的疗效及其对患者血脂水平的影响。方法选取2015年1月~2016年1月我院收治的60例老年急性老梗死合并颈动脉粥样硬化斑块患者作为研究对象,根据随机数字表法分为对照组和观察组30例,对照组患者均给予常规治疗,而观察组患者则在常规治疗的基础上给予匹伐他汀钙治疗。测量两组患者治疗前后的颈动脉内膜中层厚度(IMT)和颈动脉斑块总面积,采用神经功能缺损量表(NIHSS)和斑块积分法评价两组患者的神经功能和颈动脉粥样硬化程度。于治疗前后检测两组患者血脂水平,观察两组患者治疗过程中不良反应的发生情况。结果观察组患者治疗后的TG、TC、LDL-C的水平显著低于对照组的,差异有统计学意义(P<0.05);观察组患者治疗后的HDL-C显著高于对照组的,差异有统计学意义(P<0.05);观察组患者治疗后的IMT和斑块总面积分别为(1.18±0.49)mm和(15.42±2.38)mm^2,均明显低于对照组的(1.56±0.72)mm和(19.46±3.12)mm^2,差异有统计学意义(P<0.05);观察组治疗后的动脉斑块积分和NIHSS评分分别为(4.52±0.42)分和(7.31±0.54)分,均明显低于对照组的(5.38±0.31)分和(9.87±0.61)分,差异有统计学意义(P<0.05)。结论匹伐他汀钙用于治疗老年急性脑梗死合并颈动脉粥样硬化斑块,可有效调节血脂水平,同时其具有抗动脉粥样硬化的作用,可促进神经功能的恢复。

Objective To discuss the clinical effects of pitavastatin calcium in treatment of gerontal patients with acute cerebral infarction combined with carotid atherosclerosis and it＇ s impact of blood lipid levels. Methods 60 erontal patients with acute cerebral infarction combined with carotid atherosclerosis in our hospital from January 2015 to January 2016 were randomly selected and divided into control group and observation group with 30 patients in each. Patients in control group were treated with conventional therapy. Patients in observation groups were treated with pitavastatin calcium on the basic of control group. The intima-media thickness（IMT） and artery plaque area were measured. The neurological function and the degree of carotid artery atherosclerosis with neurological function defect scale and plaque integral method,detected the blood lipid levels before and after treatments were evaluated. The occurrence of adverse reactions during treatments was observed. Results The levels of TG,TC and LDL-C in observation group were lower than those in control group, the difference was statistically significance（P 〈 0.05）. The level of HDL-C in observation group was higher than that in control group, the difference was statistically significance（P 〈 0.05）. The IMT and artery plaque area in observation group were （1.18 ± 0.49）mm and （15.42± 2.38） mm^2, while those in control group were （1.56 ± 0.72）mm and （19.46 ± 3.12）mm^2, the differences were statistically significance（P〈 0.05）. The scores of carotid plague and NIHSS in observation group were （4.52 ± 0.42） and （7.31 ± 0.54）, which were lower than those in control group, the differences were statistically significance（P〈0.05）. Conclusion Pitavastatin calcium in treatment of gerontal patients with acute cerebral infarction combined with carotid atherosclerosis can adjust blood lipid levels, promote the recovery of neural function with the function of resistance to atherosclerosis.