水飞蓟宾治疗药物性肝损伤的研究进展

Research advances in silybin in treatment of drug-induced liver injury

药物性肝损伤是临床上常见的肝损伤类型,抗精神病类药物、抗结核药物、对乙酰氨基酚、他汀类药物等均可能引起药物性肝损伤。水飞蓟宾作为水飞蓟素提取物中最具生物活性的物质,具有抗氧化、抗炎、抗纤维化等作用,总结了水飞蓟宾在防治药物性肝损伤方面的研究进展。

Drug-induced liver injury is commonly seen in clinical practice and is usually caused by antipsychotic drugs,antitubercular agents,paracetamol,and statins. Silybin,a substance with biological activity in silymarin extract,has antioxidant,anti-inflammatory,and anti-fibrosis effects. This article summarizes the research advances in silybin in the prevention and treatment of drug-induced liver injury.