肝源性糖尿病的发病机制及诊治进展

Pathogenesis and progress in the diagnosis and therapy of hepatogenous diabetes

肝源性糖尿病是指继发于慢性肝实质损伤的糖尿病,病人多饮、多食、多尿、体重减轻症状不明显,临床上以餐后血糖升高和糖耐量降低为主要特点。其相关并发症不但加重肝细胞损伤,还会破坏机体葡萄糖稳态,临床上发病率较高但诊治不够规范。本文介绍了肝脏疾病对葡萄糖稳态的影响、近年来国内外肝源性糖尿病的诊治进展,以及肝源性糖尿病降糖药物的选择。

Hepatogenous diabetes is a kind of clinical diabetes secondary to chronic liver damage,characterized by postprandial hyperglycemia and impaired glucose tolerance.Typical symptoms,such as polydipsia,polyphagia,polyuria and weight loss are not obvious.Complications can aggravate liver cell damage and also disturb glucose homeostasis.However,its incidence is high and guildlines for diagnosis and treatment are absent.In this paper,the influence of liver diseases on glucose homeostasis,the advances in the diagnosis and treatment of hepatogenous diabetes in recent years and the therapeutic drugs were introduced.