慢阻肺加重期糖皮质激素治疗疗效观察

Curative effect observation of glucocorticoid on COPD aggravating period

目的:探讨糖皮质激素治疗慢性肺加重期患者的临床疗效。方法:随机选取我院自2014年2月~2016年2月间收治的24例慢阻肺加重期患者,将其按照随机数法分为对照组和观察组(n=12),对照组患者采用特布他林(1 mL,每日雾化吸入治疗2次,每次18min)治疗,观察组患者在对照组的基础上采用糖皮质激素治疗,在治疗前对患者的症状进行检查,观察两组患者的动脉血气指标和临床效果。结果:经过治疗,观察组患者治疗的总有效率为91.7%,显著高于对照组的76.7%(P<0.05),治疗后,观察组患者的血氧饱和度(Oxygen saturation,SpO2)、血氧张力(Oxygen tension,PaO2)、二氧化碳分压(Partial pressure of carbon dioxide,PaCO2)、pH值等动脉血气指标均明显优于对照组(P<0.05)。结论:在慢阻肺加重期患者的临床治疗中采用糖皮质激素治疗,能够有效的改善患者的动脉血气指标,临床疗效显著,值得推广。

Objective：To investigate the clinical curative effect of glucocorticoid on patients with chronic obstructive pulmonary disease aggravating period.Methods：Twenty-four COPD patients in our hospital from February 2014 to February 2016 were selected and randomly divided into control group and observation group（n=12）.All patients in control group were treated with terbutaline（1mL,daily inhalation treatment of 2times,each time for 18min）,and patients in the observation group were treated with glucocorticoid on the basis of the control group,the symptoms of the patients were examined before treatment,and the arterial blood gas parameters and clinical effects of the two groups were observed.Results：After treatment,the total effective rate in patients of observation group was 91.7%,which is significantly higher than that of control group（76.7%,P〈0.05）.And oxygen saturation（SpO2）,oxygen tension（PaO2）,partial pressure of carbon dioxide（PaCO2）and pH value,such as arterial blood gas index in observation group were significantly better than that of control group（P〈0.05）.Conclusion：Application of glucocorticoid in the clinical treatment of COPD patients aggravating stage,can effectively improve the patient′s artery blood gas index,the clinical curative effect is distinct,worthy of promotion.