早期行CRRT治疗急性重症胰腺炎的效果观察

Clinical Observation of Early Treatment of Severe Acute Pancreatitis with CRRT

目的:对早期行连续性肾脏替代疗法(CRRT)治疗急性重症胰腺炎的临床价值及效果的观察和研究。方法:整群选取自2014年8月-2016年8月在自治区人民医院重症医学科收治的急性重症胰腺炎患者70例,根据治疗方法的不同将患者随机分为对照组和试验组。对照组患者采用临床常规综合性保守疗法,试验组患者在对照组的常规治疗上联合CRRT治疗,48 h后观察并比较两组患者实验室指标、血气分析、心率、呼吸频率等变化。结果:试验组患者经CRRT治疗48 h后其实验室指标水平、血气分析结果明显优于对照组,差异有统计学意义(P<0.05);两组患者经48 h治疗后心率与呼吸频率均有好转,但试验组改善程度明显优于对照组,差异有统计学意义(P<0.05)。结论:早期采用CRRT治疗急性重症胰腺炎能够获得十分显著的临床效果,其更有效的改善患者的实验室指标、血气情况及生命体征,提高患者的生存质量。

Objective： To observate and study the clinical value and efficacy of early CRRT in the treatment of severe acute pancreatitis.Method： 70 patients with severe acute pancreatitis from August 2014 to August 2016 in the department of critical care medicine in Xinjiang Uygur Autonomous Region People＇s Hospital were selected, according to the different treatment methods, the patients were randomly divided into control group and experimental group.Patients in the control group were treated with conventional comprehensive conservative therapy, while in the experimental group were treated with CRRT combined with conventional treatment in the control group.48 hours later, the changes of laboratory indexes, blood gas analysis, heart rate and respiratory rate were observed and compared between the two groups.Result： After 48 hours of CRRT treatment, the patients in the experimental group were significantly better than the control group, the difference was statistically significant（P〈0.05）.Two groups of patients after 48 hours of treatment, the heart rate and respiratory rate were improved, but the experimental group was significantly better than the control group, the difference was statistically significant（P〈0.05）.Conclusion： Early treatment of severe acute pancreatitis with CRRT can obtain very significant clinical effect, it is more effective to improve the laboratory indicators, blood gas and vital signs, improve the quality of life of patients.