脂肪因子在自身免疫发生与调节中的作用

Role of adipokines in the occurrence and regulation of autoimmune diseases

背景:脂肪因子是一类由脂肪组织分泌的生物介质,所分泌和影响的一系列细胞因子和趋化因子。近年来,研究发现脂肪因子在促炎和抗炎调节中也起到了一定的作用。目的:分析不同类型脂肪因子在自身免疫反应及免疫疾病中的炎症调节作用,以期提出控制自身免疫疾病的进展并有效治疗疾病的策略,寻找评估病情的进展、并发症的发生以及预测患者的生存预后的有效指标。方法:以"脂肪因子,自身免疫"和"adipokine,autoimmune"为检索词,检索1986至2016年中国知网和Pub Med数据库,查询脂肪因子在自身免疫中作用的相关文献。结果与结论:脂肪组织不只在调节代谢功能中扮演了重要角色,对脂肪组织的认知随着脂肪因子对调节免疫反应的作用而不断发展。脂肪因子在机体中发挥了多种作用,对代谢和炎症有广泛的影响。自身免疫性疾病的发生仍有一部分是某些尚未明确的炎症应答因素,而随着对脂肪因子的研究不断深入,将会对自身免疫疾病的机制研究做出重大突破。

BACKGROUND： Adipokines are secreted by adipose tissue, including a series of cytokines and chemokines. Additionally, adipokines have been found to play certain roles in pro- and anti-inflammatory regulation. OBJECTIVE： To analyze the regulatory effect of various adipokines in the inflammatory process of autoimmune response and immune diseases, thus providing the strategy for controlling and treating autoimmune diseases and searching effective indexes for assessing disease development, incidence of complications and prognosis. METHODS： CNKI and PubMed databases were retrieved for the articles addressing the role of adipokines in autoimmune diseases published from 1986 to 2016 using the keywords of ＂adipokine, autoimmune＂ in English and Chinese, respectively. RESULTS AND CONCLUSION： Adipose tissue plays a critical role in metabolism regulation, and its effect on the immune system has emerged through a series of studies concerning adipokines regulating immune response. Adipokines exert various functions, and regulate metabolism and inflammation. In the development and occurrence of autoimmune diseases, some factors for immune responses remain unclear, and in-depth studies on adipokines will be helpful for lifting the veil of autoimmune diseases.