猪沙门菌疫苗研究进展

Development of swine Salmonella vaccine

沙门菌病是一种重要的人兽共患病,我国是猪肉消费大国,受污染的猪肉是沙门菌病的主要来源,目前国内外有许多猪沙门菌疫苗在被使用。在欧洲现流行的猪沙门菌疫苗为减毒活疫苗,能减少沙门菌在猪体内的定殖,并能在二次免疫后诱导高效的抗体免疫应答。接种疫苗并非万无一失,问题就在于,当沙门菌的血清型与疫苗的抗原不相同时,对沙门菌的防控效果就较差,现阶段对猪疫苗交叉保护研究较少。本文就猪沙门菌疫苗的研究进展进行了综述。

Salmonellais an important zoonosis.China is the largest pork consumer.Contaminated pork is the main source of Salmonelladisease at home and abroad.There are many swine Salmonellavaccine in use in Europe.Now the current swine Salmonellavaccine is a live attenuated vaccine,Salmonellacan reduce colonization in pigs,and can induce immune response efficiently after the two immunizations.The control effect is poor,at this stage of swine vaccine cross protection research,type of Salmonellaand vaccine antigen are not the same.This paper reviews the research progress of swine Salmonellavaccine.