内脂素与军事飞行员冠状动脉粥样硬化发病风险相关性研究

Correlations between visfatin and risk of coronary atherosclerosis among military pilots

目的明确血清内脂素(visfatin,VF)与冠状动脉粥样硬化(atherosclerosis,AS)的相关性,探讨与军事飞行员冠状动脉粥样硬化发病风险相关性。方法收集军事飞行员冠状动脉粥样硬化组(飞行员AS组)50例,普通人冠状动脉粥样硬化组(普通人AS组)50例,健康军事飞行员组200名,普通健康人组200名,通过酶联免疫吸附法(ELISA)测定各组血清VF及白介素-6(IL-6)浓度。结果飞行员AS组血清VF水平及IL-6水平均高于飞行员健康组,差异有统计学意义(P<0.05);普通人AS组血清VF水平及IL-6水平均高于普通健康人组,差异有统计学意义(P<0.05);飞行员AS组血清VF水平及IL-6水平均高于普通人AS组,差异有统计学意义(P<0.05);飞行员AS组及普通人AS组VF与IL-6水平具有相关性(P<0.05)。结论血清VF可能与血管内皮损伤的炎症反应有关,可以作为提示军事飞行员动脉粥样硬化发病风险的一项指标。

Objective To investigate the correlations between serum visfatin（VF） and coronary atherosclerosis （AS） amongmilitary pilots. Methods Fifty military pilots with coronary atherosclerosis, 50 ground crew with coronary atherosclerosis, 200 healthy military pilots and 200 healthy ground crew were enrolled in this study. The serum VF and IL-6 levels were measured with enzyme linked immune sorbent assay （ELISA）. Results The serum VF levels and IL-6 levels in the group of military pilots with coronary atherosclerosis were significantly higher than those of the healthy military pilot group （P〈0.05）, the serum VF levels and IL-6 levels in the group of ground crew with coronary atherosclerosis were significantly higher than that of the healthy ground crew group （P〈0.05）, and the serum VF levels and IL-6 levels in the group of military pilots with coronary atherosclerosis were significantly higher than those of the ground crew group with coronary atherosclerosis （P〈0.05）. VF levels were related to IL-6 levels in the group of military pilots with coronary atherosclerosis and the group of ground crew with coronary atherosclerosis （P〈0.05）. Conclusion VF can be regarded as an indicator of the risk of coronary atherosclerosis among military pilots.