千金苇茎汤合麻杏石甘汤联合阿奇霉素治疗肺炎支原体肺炎疗效观察

Observation on the curative effect of Qianjin Weijing decoction and Maxing Shigan decoction combined with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia

目的观察千金苇茎汤合麻杏石甘汤联合阿奇霉素对肺炎支原体肺炎治疗效果。方法 2015年5月至2016年5月深圳市福田区中医院儿科收治住院的肺炎支原体肺炎患儿50例,随机分为观察组与对照组各25例。对照组单用阿奇霉素治疗4个周期,观察组采用千金苇茎汤合麻杏石甘汤联合阿奇霉素治疗4个疗程,观察两组治疗效果及咳嗽、咳痰、病灶消失时间、治疗后发热持续时间、不良反应发生率。结果观察组治疗总有效率为96.0%(24/25),显著高于对照组76.0%(19/25),差异有统计学意义(P<0.05);观察组患儿咳嗽、咳痰、病灶消失时间、治疗后发热持续时间均较对照组短,差异有统计学意义(P<0.05);观察组治疗后不良反应发生率为12.0%(3/25),显著低于对照组36.0%(9/25),差异有统计学意义(P<0.05)。结论千金苇茎汤合麻杏石甘汤联合阿奇霉素治疗肺炎支原体肺炎效果显著,可缩短症状改善时间,也能抵消阿奇霉素所致不良反应,是一种安全性且有效的治疗方案,值得临床推广。

Objective To explore the curative effect of Qianjin Weijing decoction and Maxing Shigan decoction combined with azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia. Methods Fifty cases of children with Mycoplasma pneumoniae pneumonia in our hospital from May 2015 to May 2016 were selected as the research objects and were randomly divided into the observation group and the control group with 25 cases in each group. Patients in the control group were treated with azithromycin for 4 cycles, while patients in the observation group were treated with Qianjin Weijing decoction and Maxing Shigan decoction combined with azithromycin for 4 cycles. The extinction time of cough, expectoration, and focus, duration of fever after treatment and the incidence of adverse reactions in children in two groups were observed. Results The extinction time of cough, expectoration and focus, and duration of fever after treat- ment in the observation group were shorter than those in the control group and the difference was statistical- ly significant （P〈0.05）. The incidence of adverse reactions in the observation group was 12.0% （3/25）, and compared with 36.0% （9/25） in the control group, the difference was statistically significant （P〈 0.05）. Conclusion Qianjin Weijing decoction and Maxing Shigan decoction combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia has significant effect. This treatment can not only shorten the time of symptom improvement, but also offset the adverse reaction caused by azithromycin, which is safe and effective and worthy of promotion.