硒酵母结合常规疗法治疗儿童慢性感染性腹泻临床疗效分析

Clinical effects analysis of selenium yeast combined with conventional therapy in treatment of children with chronic infectious diarrhea

目的探讨硒酵母治疗儿童慢性感染性腹泻的临床疗效。方法 2015年1月至2016年7月湖南省儿童医院感染科收治住院的慢性感染性腹泻患儿56例,随机分为观察组和对照组各28例。对照组给予调整饮食、保护胃肠黏膜、口服补液盐Ⅲ常规治疗;观察组在对照组治疗基础上口服硒酵母混悬液,疗程均14d。比较两组患儿排便频率和粪便性状。结果观察组患儿自服药第6天至疗程结束,观察组排便正常率均高于对照组,差异有统计学意义(P<0.05)。观察组患儿自服药第6天至疗程结束,观察组粪便性状正常率均高于对照组,差异有统计学意义(P<0.05)。未发现因口服硒酵母而引起的不良反应。结论硒酵母治疗小儿感染性腹泻效果好,且无明显不良反应,值得临床推广应用。

Objective To explore the clinical effects of selenium yeast in the treatment of children with chronic infectious diarrhea. Methods We enrolled 56 children with infectious diarrhea in our hospital. They were randomly divided into observation group （n =28） and control group（n = 28）. In the control group, the 28 children received conventional treatment of conditioning diet, mucous membrane protection and reasonable fluid infusion. In the observation group, the 28 children received treatment of oral selenium yeast in addition to the conventional treatment. After the course of treatment of 14 days, we compared the clinical effects of the two groups, including frequency of bowel movement and the shape and property of fe- ces. Results From the 6th day to the end of the treatment course, the rate of normal defecation in the obser- vation group was higher than that of the control group（P〈0.05）. Similarly, the rate of normal feces in the observation group was higher than the control group（P〈0.05）. There was no adverse reactions related to selenium yeast. Conclusion Selenium yeast has good effect in the treatment of children with chronic infec- tious diarrhea, and there is no obvious adverse reaction, so it is worthy of clinical application.