单唾液酸四己糖神经节苷酯结合丹参注射液对足月新生儿缺氧缺血脑病的临床疗效观察

Observation of clinical curative effect of monosialotetrahexosylganglioside combined with salvia injection on hypoxic ischemic encephalopathy of term neonates

目的观察单唾液酸四己糖神经节苷酯(GM1)结合丹参注射液治疗足月新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将105例足月HIE患儿随机分为治疗组(常规治疗加GM1和丹参注射液)52例及对照组(常规治疗加胞二磷胆碱)53例治疗3疗程,观察患儿治疗前后行为神经评分(NBNA)和总体临床疗效以及1周岁时预后和精神运动发育商(DQ)等指标。结果治疗后治疗组较对照组NBNA、总体临床疗效、1周岁时的DQ均有不同程度的改善(P<0.05)。结论 GM1结合丹参注射液对HIE患儿有较好的近期治疗作用和改善较远期的预后,值得临床推广。

Objective To observe clinical curative effect of monosialotetrahexosylganglioside （GM1） combined with salvia injection on hypoxic ischemic encephalopathy （HIE） of term neonates. Methods 105 term neonates with HIE were randomly divided into the treatment group with 52 cases and the control group with 53 cases. The treatment group was given routine treatment combined with salvia injection while the control group was given routine treatment combined with citicoline. Neonatal behavior neurological assessment （NBNA）, total clinical curative effect, prognosis and psychomotor developmental quotient （DQ） of one year old and other indexes before and after treatment of term neonates were observed. Results NBNA, total clinical curative effect and DQ of one year old were all had different degrees of improvement （P 〈 0.05）. Conclusion GM1 combined with salvia injection has a better recent treatment effect on term neonates with HIE and it can improve long-term prognosis, which is worthy of clinical promotion.