乳腺癌患者化疗致败血症并发症的临床治疗观察

Clinical treatment observation of complications caused by chemotherapy in patients with breast cancer

目的研究乳腺癌患者化疗致败血症并发症的临床治疗观察。方法针对本次对乳腺癌化疗致败血症并发症的临床治疗观察的研究,将我院内2012年6月~2016年6月收治的1200例乳腺癌化疗患者中22例化疗致败血症患者作为临床研究对象,采用回顾性分析的方式对其治疗方式和效果进行分析。结果本次研究中入选的22例患者中20例患者因化疗后出现严重骨髓抑制的患者,以高热为首诊症状就诊,血常规检查提示四度粒细胞缺乏,经血培养检查证实败血症,血液中培养出革兰氏阴性菌。2例患者因行Port化疗管道感染,导致败血症,血液中培养出革兰氏阳性菌,及时发现后拔除输液港管道,积极抗感染治疗后痊愈。22例化疗乳腺癌致败血症患者总治愈率为100.00%。结论乳腺癌患者化疗致败血症并发症形成的因素主要包含抵抗力下降、局部护理不当、血栓形成等因素,但及时发现、经积极治疗后对患者的生命安全无影响,通过给予有效的抗生素抗感染治疗、提高免疫力治疗、及时拔除感染管道等措施处理后败血症症状能短期内缓解,治疗效果显著。

Objective To study the clinical treatment of complications caused by chemotherapy in patients with breast cancer. Methods For the clinical observation on the treatment of the complications caused by sepsis on breast cancer chemotherapy, 22 cases of chemotherapy induced sepsis patients in 1200 cases of breast cancer patients in our hospital during June 2012 to June 2016 were selected as a clinical study. Retrospective analysis method was used to analyze the treatment method and effect. Results Among the 22 cases in this study, 20 patients were severe bone marrow suppression after chemotherapy in patients with high fever, primary symptom treatment. Blood routine examination showed four degree of neutropenia, blood culture confirmed septicemia, gram negative bacteria in blood culture. 2 cases of patients were port chemotherapy pipeline infection, leading to sepsis, blood culture of gram positive bacteria, found in time after the removal of the port of transfusion, positive anti infection treatment after recovery. The total cure rate of 22 cases of septicemia caused by chemotherapy of breast cancer was 100%. Conclusion The factors of the formation of septic complications caused by chemotherapy in patients with breast cancer includes decreased resistance, inappropriate local care, thrombosis and other factors, but the timely discovery, after active treatment on the life safety of patients without symptoms of sepsis can influence. Through short-term relief to give effective antibiotic anti infection treatment, improving immunity, timely treatment removal of infected pipeline measures and other treatment, the symptoms can be relieved in the short term. It has significant treatment effect.