雷公藤红素在治疗代谢综合征中的作用及相关机制

Effects and related mechanisms of celastrol in the treatment of metabolic syndrome

雷公藤红素是从中药雷公藤的根皮中分离得到的有效成分之一，具有抗肿瘤、抗病毒、免疫抑制等活性。最近研究发现，其可通过改善胰岛素抵抗，增加瘦素受体敏感性和能量消耗，抑制脂肪细胞分化，抗炎和抗氧化等机制减轻体重和改善糖、脂代谢，表明雷公藤红素在治疗代谢综合征及相关异常中具有潜在作用。

Celastrol, one of the most promising medicinal ingredient extracted from the root of Tripterygiumwilfordii Hook, possesses anti-tumor, anti-virus and immunosuppressive effect. Recent researches showed its effects on reducing body weight, alleviating glucose and lipid, the possible mechanisms included reversing insulin resistance, increasing leptin sensitivity and energy expenditure, inhibiting adipocyte differentiation, anti-inflammatory, anti-oxidant and so on. It indicates celastrol plays potential roles in the treatment of metabolic syndrome and related dysfunction.