p53与物质能量代谢的关系

Relationship between p53 and material, energy metabolism Xiang Fenfen

p53是肿瘤抑制基因，也是参与调节各种反应的转录因子，其表达的蛋白是一种能够激活或者抑制下游基因转录的核蛋白。由于细胞种类、应激状态、所处环境以及细胞内p53表达状态的不同，p53通过多种不同的细胞通路来参与调节糖代谢、脂代谢、能量代谢，甚至与代谢性疾病的发生有一定的关系。

p53 is not only a tumor suppressor but also a transcription factor which involved in regulating different kinds of reaction. The expression of p53 is a kind of nucleoprotein which can activate or inhibit a variety of down-stream gene＇s transcription. Because of different kinds, states, environment of cells, and the state of p53 expression in cells, p53 participates in a variety of cellular pathways to regulate glucose metabolism, lipid metabolism, energy metabolism, even metabolic disease.