短链脂肪酸在2型糖尿病发病机制中的作用

The role of short chain fatty acids in the pathogenesis of type 2 diabetes mellitus

短链脂肪酸（SCFA）是由肠道菌群发酵膳食纤维产生的代谢产物，饮食结构变化通过改变肠道菌群结构与功能，影响SCFA的产生。近来研究发现，SCFA通过调节胃肠道激素分泌、胰岛素敏感性及糖、脂代谢，参与了2型糖尿病的发生、发展。对SCFA的深入研究，为阐明2型糖尿病发病机制及其预防和治疗提供了新的思路和靶点。

Short chain fatty acids （SCFA） are metabolic products of the gut microbiota fermentation of dietary fiber, and are influenced by the structure and function of gut microbiota with the change of diet. Recent studies have indicated that SCFA may play an important role in the pathogenesis of type 2 diabetes mellitus, which is involved in the regulation of secretion of gut hormones, insulin sensitivity, glucose and lipid metabolism and so on. Further researches related to SCFA may provide a new measure and target to clarify the pathogenesis of type 2 diabetes mellitus as well as to prevent and treat it.