摘要
在氨基化改性的四氧化三铁(Fe_3O_4)纳米粒子表面引发N-羧酸酐L-谷氨酸苄酯(BLG-NCA)开环聚合,制得四氧化三铁/聚L-谷氨酸苄酯(PBLG)复合材料(Fe_3O_4-g-PBLG).改变单体和引发剂比例可以调控Fe_3O_4-g-PBLG的接枝率,采用热失重分析(TGA)测得实际接枝率分别为66.36%,79.66%和89.52%.通过双乳液挥发法制备磁性Fe_3O_4-g-PBLG多孔微载体,其中接枝率为89.52%的微载体密度为1.034 g/m L,孔隙率为92.57%,粒径为200~300μm,孔径为40~50μm,保水率为370%~400%.同时Fe_3O_4-g-PBLG微载体具有超顺磁性,在外加磁场作用下可排布成任意形状,对治疗复杂结构的骨缺损具有显著优势.因此Fe_3O_4-g-PBLG多孔微载体在骨组织工程领域具有潜在应用价值.
Ferroferric oxide/poly (γ-benzyl-L-glutamate) ( PBLG ) composite materials ( Fe3O4-g-PBLG ) was synthesized by initiating y-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) polymerization on the surface of amino-functionalized ferroferrie oxide(Fe3O4) nanopartieles. Fe3Oa-g-PBLG composites was confirmed by Fourier transform infrared and X-ray diffraction. Thermogravimetric (TGA) study showed that the grafting ratios of Fe3O4-g-PBLG were 66. 36%, 79.66%, and 89.52%, and grafting ratio of Fe3O4-g-PBLG composite could be controlled. The Fe3O4-g-PBLG with grafting ratio of 89.52% was used to fabricate magnetic Fe3O4-g-PBLG porous mieroearriers. The porous microcarriers possessed suitable density( 1. 034 g/mL) , porosity(92.57% ) , particle size ( 200--300 μm), pore size ( 40-50μm) and water retention ( 370%-400% ). Meanwhile, mieroearriers exhibited superparamagnetism. Under the action of magnetic fields, the mierocarriers can be arranged into any shape, showing significant advantages for the treatment of complex structure of the bone defects. These results showed that Fe3O3-g-PBLG porous microearriers might be applied in bone tissue engineering.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2017年第7期1295-1302,共8页
Chemical Journal of Chinese Universities
基金
上海市科委基础研究重点项目(批准号:15JC1490400)
国家自然科学基金(批准号:51373094)资助~~
关键词
四氧化三铁
聚L-谷氨酸苄酯
多孔微载体
磁性能
骨组织工程
Fe3O4
Poly (γ-benzyl-L-glutamate ) (PBLG)
Porous microearrier
Magnetic property
Bone tissue engineering