^(125)I粒子组织间植入联合高频热疗治疗复发性宫颈癌近期疗效观察

Interstitial Permanent Implantation of ^(125)I Seeds Combined with High-Frequency Hyperthermia for Recurrent Cervical Cancer

目的探讨^(125)I粒子植入联合深部高频热疗治疗复发性宫颈癌的近期临床疗效和安全性。方法将52例盆腔复发性宫颈癌患者分为治疗组和对照组,各26例,治疗组采用^(125)I粒子植入联合高频热疗,对照组采用单纯^(125)I粒子植入,观察两组肿瘤消退情况,此外进行疼痛缓解疗效评估和不良反应评估,组间比较采用卡方检验。结果治疗后2个月,治疗组总有效率(96.2%)高于对照组(73.1%)(χ~2=8.35,P<0.05),疼痛缓解率(88.2%)高于对照组(38.9%)(χ~2=5.33,P<0.05)。治疗后1个月,治疗组急性放射损伤不良反应率和对照组比较,差异无统计学意义(χ~2=2.79,P>0.05)。结论^(125)I粒子植入联合高频热疗治疗复发性宫颈癌近期临床疗效较好,不良反应少。

Objective To explore the clinical value and safety of radioactive ^125I combined with high-frequency hyperthermia in the treatment of patients with recurrent cervical cancer. Methods A total of 52 cases randomly divided into two groups,with 26 patients in each group,were collected. The observation group accepted^125I seeds combined with high-frequency hyperthermia in treatment,while the control group only received simple particle implantation. The control of tumor response,local control rate of pain relief and the adverse reactions were evaluated. A comparison between groups was done using Chi-square test. Results Two months after treatment,the response rate of the tumor was 96. 2% in the observation group,which was higher than that in the single treatment group（ 73. 1%; χ^2= 8. 35,P〈0. 05）. Response rates of pain relief were 88. 2% and 38. 9%（ χ^2= 5. 33,P〈0. 05）. One month after treatment,there was no significant difference in the prevalence of adverse effects between the two groups（ χ^2= 2. 79,P〈0. 05）. Conclusion Interstitial permanent implantation of^125I seeds combined with high-frequency hyperthermia for recurrent cervical cancer has a good short-term response and less adverse reactions.