根治切除术联合抗病毒治疗肝癌合并乙肝病毒感染的临床研究

The Clinical Outcomes of Hepatocellular Carcinoma Complicated With Hepatitis B Virus(HBV) Infection Treated by Radical Resection Combined With Antiviral Therapy

目的探讨根治切除术联合抗病毒治疗肝癌合并乙肝病毒(HBV)感染的临床效果。方法选取72例我院于2016年3月—2017年3月所收治的肝癌合并乙肝病毒感染患者,将患者随机分为对照组和观察组,两组均行根治切除术,观察组加施抗病毒治疗,比较两组治疗前后的肝功能和HBV-DNA水平及并发症的产生情况。结果两组患者治疗前肝功能及HBV-DNA水平差异无统计学意义(P>0.05),治疗后均明显改善,观察组治疗后肝功能及HBV-DNA水平优于对照组;观察组并发症的产生率为11.11%,低于对照组的27.78%,差异具有统计学意义(P<0.05)。结论针对肝癌合并乙肝病毒感染患者,行根治切除术联合抗病毒治疗可有效改善患者肝功能及病毒指标,降低并发症的产生,是一种安全有效的治疗方式。

Objective To explore clinical outcomes of hepatocellular carcinoma complicated with hepatitis B virus（HBV） infection which treated by radical resection combined with antiviral therapy. Methods 72 cases of hepatocellular carcinoma with hepatitis B virus infection patients were selected and randomly divided into control group and observation group in our hospital, from March 2016 to March 2017. Both groups underwent radical resection. The observation group was add treated with antiviral therapy.The liver function and HBV-DNA levels and the occurrence of complications were compared between the two groups before and after treatment.Results There was no significant difference in liver function and HBV-DNA level between the two groups before treatment（P〈0.05）.After treatment all were significantly improved.The level of liver function and HBV-DNA in the observation group was significantly better than that in the control group after treatment.The incidence of complications in the observation group was 11.11%,significantly lower than the control group of27.78%,the difference was statistically significant（P〈0.05）.Conclusion For hepatitis B patients with hepatitis B virus infection,using radical resection combined with antiviral therapy can effectively improve the liver function and virus indicators,reducing the incidence of complications,it’s a safe and effective treatment method.