血液灌流抢救重症急性中毒患者的临床疗效

Clinical Efficacy of Hemoperfusion in the Treatment of Severe Acute Poisoning

目的观察分析血液灌流抢救重症急性中毒患者的临床疗效。方法收集我院诊治的40例重症急性中毒患者作为研究对象,对其均采用"常规治疗+血液灌流"法进行治疗,采用回顾性分析法观察其临床疗效,血液灌流治疗前后分别测定每位患者血清IL-6和TNF-α含量。结果 40例纳入对象中治疗总有效患者37例(92.5%),3例家属放弃治疗发生死亡(7.5%);生存患者治疗后血清IL-6及TNF-α含量较治疗前均降低(P<0.05)。结论常规治疗基础上对急性中毒患者进行血液灌流抢救治疗,能降低血清IL-6和TNF-α含量,治疗疗效上升,死亡率降低。

Objective To observe and analyze the clinical efficacy of hemoperfusion in the treatment of severe acute poisoning patients. Methods 40 cases of severe acute poisoning were collected from our hospital. All patients were treated with routine treatment plus hemoperfusion. The clinical efficacy was observed by retrospective analysis. Serum IL-6 and TNF-α were measured before and after hemoperfusion. Results Of the 40 patients, 37 were effective（92.5%）, and 3 patients died（7.5%）. The serum levels of IL-6 and TNF-α in patients with survival were lower than those before treatment（P〈0.05）. Conclusion Hemoperfusion treatment for patients with acute poisoning on the basis of routine treatment can reduce the serum levels of IL-6 and TNF-alpha, and the treatment effect increases and the mortality decreases.