3项指标检测在细菌感染诊断中的临床价值研究

The Clinical Value of 3 Indexes in the Diagnosis of Bacterial Infection

目的分析探讨血清降钙素原(PCT)、单核细胞HLA-DR以及中性粒细胞CD64三项指标检测在细菌感染诊断中的临床价值。方法随机抽取2015年3月—2016年3月在我院确诊为血液感染的患者80例作为研究对象,其中确诊为血液细菌感染的患者40例作为A组,另外40例非血液细菌感染患者为B组,同时抽取在我院进行健康检查的体检者40例为C组。检测三组研究对象的血清降钙素原水平、单核细胞HLA-DR以及中性粒细胞CD64指标情况,根据检测结果分析其临床价值。结果 A组的血清降钙素原水平、中性粒细胞CD64指标高于B组、C组,单核细胞HLA-DR指标低于B组、C组(P<0.05)。B组中性粒细胞CD64水平高于C组(P<0.05),血清降钙素原水平、单核细胞HLA-DR与C组差异无统计学意义(P>0.05)。结论与其它炎性指标相比,降钙素原、单核细胞HLA-DR以及中性粒细胞CD64是比较好的细菌感染检测指标,三者联合检测更有利于对血液细菌感染患者的早期诊断和评估,提供准确的诊断依据。

Objective To investigate the clinical value of serum procalcitonin（PCT）, monocyte HLA-DR and neutrophil CD64 three markers in the diagnosis of bacterial infection. Methods Randomly selected from March 2015 to March 2016 in our hospital diagnosed as blood infection in 80 patients as the research object, which was diagnosed as bacterial infections of the blood of 40 patients as A group, another 40 cases of non bacterial infections of the blood as group B was detected, at the same time taken for body health examination in our hospital of 40 cases as group C. The serum procalcitonin level, monocyte HLA-DR and neutrophil CD64 index of three groups of subjects were detected, and their clinical value was analyzed according to the test results. Results Serum procalcitonin level and neutrophil CD64 index in group A were significantly higher than those in group B and group C, and the HLA-DR index of monocytes was significantly lower than that in group B and group C（P〈0.05）. The CD64 integral of neutrophil in group B was higher than that in group C（P〈0.05）, serum procalcitonin level, monocyte HLA-DR and C group were not significantly different（P〉0.05）. Conclusion Compared with other inflammatory markers, procalcitonin, HLA-DR of monocyte and neutrophil CD64 are better bacterial infection detection index, the three joint detection is beneficial to early diagnosis and evaluation of patients with bacterial infections of the blood, provide basis for accurate diagnosis.