呼吸机相关肺炎病原菌、耐药性及病死率的临床分析

Clinical Analysis on Mortality,Pathogens and Antimicrobid Resistance for Ventilator-Associated Pneumonia

目的 :了解呼吸机相关肺炎 (VAP)病死率、病原菌药敏情况。方法 :对 1 1 6例机械通气患者的资料加以整理分析。结果 :VAP发生率 50 .9% ;感染组病死率 55.9% ,极明显高于非感染组 (P<0 .0 1 ) ,混合感染组病死率 86.7% ,高于单一感染组 (P<0 .0 5)。致病菌以 G-杆菌为主 ,占 60 .4% ,主要为铜绿假单孢菌、大肠埃希氏菌及不动杆菌。 G+菌占 2 1 .9% ,以金葡菌为主。上述 4种细菌对常用抗生素耐药性普遍较高 ,特别是对第三代头孢菌素耐药性增加。结论 :正确合理使用抗生素对

Objective:To investigate the mortality of ventilator associated pneumonia (VAP),pathogens and antimicrobial resistance.Methods:A total of 116 patients required mechanical ventilation were analyzed.Results:The incidence of VAP was 50.9%,and the mortality in VAP group was 55.9%,which was obviously higher than that in the non VAP group ( P <0.01).The mortality of mixed infection group 86.7%, was significantly higher than that of simple infection group ( P <0.05).G - bacilli which has the occupancy of 60.4%, were the main organisms,such as Pseudomonas aeruginosa,colibacillus and acinetobacter.G + pathogens were 21.9%,and among them,staphylococcus aureus took the majority.The leves of resistance of the 4 mentioned bacterials to antibiotics was higher,especially to third generation cephalosporins.Conclusion:Antibiotics may play a positive role in preventing VAP if properly used.