贝尼地平对急性心肌梗死患者血清白细胞介素17和白细胞介素10水平的影响

Effect of Benidipine on levels of serum interleukin-17 and Interleukin-10 in patients with acute myocardium infarction and safety analysis

目的:观察贝尼地平对急性心肌梗死(AMI)患者血清白细胞介素17(IL-17)和白细胞介素10(IL-10)水平的影响及其临床应用安全性分析。方法:选择AMI患者124例,将其随机分为两组:观察组62例(常规治疗+贝尼地平2mg/d)和对照组62例(仅予常规治疗),于入院当天及第3、7、14天清晨采集患者肘静脉空腹血,采用双抗体夹心酶联免疫吸附法测定血清IL-17和IL-10水平。测量并记录观察期间所有患者每日晨起静卧位血压。结果:两组患者血清IL-10水平在住院当天及第3、7、14天比较差异无统计学意义。住院期间两组患者收缩压、舒张压比较差异无统计学意义。与对照组相比,观察组血清IL-17水平在住院当天及第3天比较差异无统计学意义(P>0.05);而在第7、14天IL-17水平显著降低,有统计学差异(P<0.05)。结论:在不影响患者血压的前提下,贝尼地平可通过降低血清IL-17水平,使AMI的炎性反应更快趋于稳定。

Objective：To observe the effect of benidipine on serum interleukin-17 （IL-17） and interleukin-10（IL-10） levels in patients with acute myocardium infarction（AMI） and analysis the safety of benidipine.Methods：124 cases of AMI patients were enrolled in the study and randomly divided into 2 groups： observation group（n=62, regular treatment＋ Benidipine 2mg/d） and control group（n=62, omly regular treatment）.The serum IL-10 and IL-17 levels were detected on the 1st day, the 3rd day, the 7th day and the 14th day in hospital by ELISA, and the blood pressure were measured and recorded during the observation period.Results：There were no statistical difference of the serum IL-10 levels on the 1st /3rd/7th/14th day between 2 groups;The systolic pressure and diastolic pressure during the observation period had no statistical difference between 2 groups;Compared with the control group, the IL-17 levels on the 1st /3rd day were also no statistical difference, but on the 7th/14th day in observation group were significantly lower.Conclusion：Benidipine can make the inflammatory reaction of AMI tend to stable faster without declining blood pressure.