FOXP1与Livin在弥漫大B细胞淋巴瘤中的表达及临床意义

The relationship and clinical significance of FOXP1 and Livin two expression in diffuse large B cell lymphoma

目的:探讨FOXP1、Livin在弥漫大B细胞淋巴瘤(DLBCL)的表达及相关性。方法:选取经病理确诊的DLBCL患者76例作为观察组,以反应性淋巴结增生患者42例作为对照组。观察组中根据不同指标分组:低危组36例和高危组40例;Non-GCB组41例和GCB组35例;结内组43例和结外组33例;无B症状组45例和有B症状组31例。每组均检测FOXP1和Livin的表达及二者的相关性。结果:观察组中Livin、FOXPI表达均明显高于对照组,差异有统计学意义(P<0.05);Livin、FOXPI在高危组、Non-GCB组高表达患者较多,和对应的低危组、GCB组比较,差异有统计学意义(P<0.05);Livin在有B症状组高表达患者较多,和无症状组比较,差异有统计学意义(P<0.05);Livin、FOXPI在Non-GCB型DLBCL中呈正相关。结论:FOXP1、Livin在DLBCL中均有高表达,且和DLBCL的原发部位、IPI评分、病理类型等有关;其有望成为判断DLBCL预后的指标。

ObjectiveTo investigate the expression and correlation of FOXPI and Livin in diffuse large B cell lymphoma （DLBCL）. Methods： 76 cases of DLBCL diagnosed by pathology were selected as observation group,42 cases of reactive lymph node hyperplasia were used as control group. The observation group was grouped according to different indexes： Low risk group 36 cases and high risk group of 40 cases;Group non-GCB 41 cases and GCB group of 35 cases;There were 43 cases in the intra node group and the other in the extranodal group （n=33） ;There were no B symptoms in 45 cases and 31 cases of B symptom group. The expression of FOXPI and livin were detected in each group and the correlation between the two groups. Results：The expression of Livin and foxpi in the observation group were significantly higher than those in the control group？the difference was statistically significant（P〈0. 05） ; Livin, FOXPI in high-risk group？non-GCB group of patients with high expression was more,They were compared with the corresponding low risk group,GCB group（P 〈0. 05） ;Livin was higher in patients with B symptoms,compared with asymptomatic group（P〈0. 05） ; Livin,FOXPI was positively correlated with type DLBCL non-GCB . Conclusion：FOXPI and Livin have high expression in DLBCL,It is related to the primary site of DLBCL,IPI score,pathological type and so on;It is expected to be a prognostic indicator for DLBCL.