血液相关标志物与社区获得性肺炎CURB-65评分的相关性研究

Relevant research about blood related indicators and CURB-65 score of community-acquired pneumonia

目的通过检测社区获得性肺炎(CAP)患者血液相关标志物的含量,分析其与CURB-65评分的相关性,为临床诊断、治疗方案的制定及调整提供依据。方法依据CURB-65评分将97例CAP患者分为高危组(n=13)、中危组(n=69)和低危组(n=15),入院24 h内抽血检测C-反应蛋白(CRP)、纤维蛋白原(FIB)、降钙素原(PCT)、D-二聚体(D-D)、白介素-6(IL-6)、白细胞(WBC)及中性粒细胞百分比(N%),分析其与CURB-65评分的相关性。结果高危组患者的CRP、PCT、D-D和IL-6水平明显高于中、低危组患者(P<0.01);FIB水平比较,高危组与中、低危组之间差异无统计学意义(P>0.05);WBC计数和N%,高危组高于低、中危组患者(P<0.01)。除FIB外,各指标与CURB-65评分均呈正相关,差异具有统计学意义(P<0.01)。结论 CRP、PCT、D-D、IL-6和N%均与CAP严重程度呈正相关,其中CRP、PCT和IL-6检测能够更好的评估疾病严重程度,有助于CURB-65评分,提高其准确度,具有重要的临床意义,值得推广。

Objective To analyze the relationship between biomakers and CURB-65 score by detecting the content of biomarkers in community-acquired pneumonia （CAP） patients, in order to provide the basis for clinical diagnosis and therapeutic schedule.Methods 97 CAP patients were divided into the high-risk group （n=13）, the average-risk group （n=69） and the low-risk group （n=15） by CURB-65 score.Within 24 hours after admission, the levels of C-reactive protein （CRP）, fibrinogen （FIB）, calcitonin （PCT）, D-dimer （D-D）, and interleukin 6 （IL-6）, white blood cell （WBC）, and neutrophil percentage （N%） were detected, and its relevance to CURB-65 score was analyzed.Results The levels of CRP, PCT, D-D and IL-6 were obviously higher in the high-risk group than in the average-risk group and the low-risk group （P〈0.01）.The level of FIB showed no statistical significance among the three groups （P〉0.05）.WBC count and N % was significantly higher in the high-risk group than in the average-risk group and the low-risk group （P〈0.01）.Except FIB, the other indexes had a positive correlation with CURB-65 score （P〈0.01）.Conclusion CRP, PCT, D-D, IL-6 and N % are positively correlated with CAP severity.The CRP, PCT and IL-6 test can better assess the severity of disease, and contribute to improve CURB-65 score, which has important clinical significance.