N-乙酰半胱氨酸雾化吸入治疗老年AECOPD患者的临床观察

Clinical observation on N-Acetylcysteine inhalation in treatment of elderly patients with AECOPD

目的探讨评价在老年慢性阻塞性肺疾病急性加重期(AECOPD)患者中使用N-乙酰半胱氨酸(NAC)雾化吸入治疗的临床疗效。方法将60例IV级AECOPD患者随机分为观察组和对照组各30例,两组均给予常规治疗,观察组在常规治疗的基础上加用N-乙酰半胱氨酸(NAC)雾化吸入,2次/天。在入院第1天和入院后第14天测定比较两组患者血气分析(PaO_2、PaCO_2)、肺功能(FEV_1%prd、FEV_1/FVC%)及血清中CRP、PCT水平。结果治疗第14天两组患者血气分析(PaO_2、PaCO_2)、肺功能(FEV_1%prd、FEV_1/FVC%)及血清中CRP、PCT水平均有好转(P<0.05),且观察组较对照组改善更加明显,差异有统计学意义(P<0.05)。结论 N-乙酰半胱氨酸(NAC)雾化吸入辅助治疗可明显改善老年AECOPD患者的临床症状和肺功能,减轻炎症反应,且安全有效。

Objective To observe the clinical efficacy and safety of N-acetylcysteine Inhalation in treatment of elderly patients with AECOPD.Methods 60 patients with AECOPD were randomly divided into two groups.The control group （n=30） received conventional therapy, while the observation group （n=30） received additional NAC inhalation （2/d）.Blood gas analysis （PaO2, PaCO2）, pulmonary function （FEV1%prd, FEV1/FVC%） and the serum levels of CRP and PCT were evaluated on Day 1 and 14.Results 14 days after treatment, their blood gas analysis, pulmonary function and the serum levels of CRP and PCT all improved （P〈0.05）, and the improvement was more pronounced in the observation group than in the control group （P〈0.05）.Conclusion NAC inhalation is an effective and safe method in treatment of elderly patients with AECOPD.