肺癌合并肺栓塞危险因素及预后的临床分析

Risk Factors and prognosis of lung cancer complicated with pulmonary embolism

目的本研究通过患者临床资料和治疗详细记录等分析探讨肺癌合并肺栓塞的相关危险因素并分析预后。方法通过我院收治的32例肺癌且合并肺栓塞患者(作为研究组)的临床资料进行分析,另外64例肺癌但没有患肺栓塞的患者作对照组。先经过单因素分析,再通过logistic回归分析危险因素。最后用Kaplan-Meier进行生存分析患者的预后情况。结果单因素分析结果为血红蛋白>150g/L、癌症处于Ⅲ-Ⅳ期即中晚期、血氧分压<70mm Hg、腺癌四个因素。预后结果则显示,肺癌合并肺栓塞患者(研究组)的生存时间明显比不伴有肺栓塞的患者(对照组)更短。结论腺癌、血红蛋白、血氧分压以及Ⅲ-Ⅳ期是肺癌合并肺栓塞的危险因素。并且肺癌伴有肺栓塞的患者生存时间更短。

Objective To investigate the risk factors associated with pulmonary embolism in patients with lung cancer by analyzing clinical data and treatment details.Methods The clinical data of 32 patients with lung cancer and pulmonary embolism （as the treatment group） were analyzed with statistics, and at the same period, 64 patients only with lung cancer were treated as the control group.First, it used univariate factor analysis to identify some high risk factors.Then, conditional logistic regression analysis was applied to filter out the related risk factors.Finally, their prognosis was also compared with matched controls via Kaplan-Meier survival analysis.Results The results of univariate factor analysis included serum hemoglobin〉 150g/L, stage Ⅲ-Ⅳ, partial pressure of oxygen〈 70mmHg, respectively.The survival time in patients with pulmonary embolism was remarkably lower than that in patients without pulmonary embolism.The survival time in patients undergoing chemotherapy was longer than without undergoing chemotherapy.Conclusion Adenocarcinoma, late stage disease and high serum hemoglobin are important risk factors for lung cancer patients with concomitant pulmonary embolism.The survival time in patients without chemotherapy is lower.