姜黄素-赖氨酸共晶在无水乙醇中的热力学研究

Thermodynamics of Curcumin-lysine Cocrystal in Anhydrous Ethanol

目的考察在三元体系中各条件下的平衡状态,计算姜黄素共晶的相关热力学常数,探讨无水乙醇作为特异性溶剂的合理性。方法采用溶液法分别测定姜黄素在不同温度下、不同浓度赖氨酸的无水乙醇中的溶解度,通过数学推导,得出姜黄素共晶的热力学常数。结果绘制了姜黄素-赖氨酸-无水乙醇的三元相图,并求得了K_(sp)、K_(ll)、△G°、△H及△S等热力学参数。结论无水乙醇可以作为特异性溶剂用于提取姜黄素共晶中混杂的姜黄素单体。

OBJECTIVE To calculate the thermodynamic constant of a ternary systerm made up with curcumin, lysine and anhydrous ethanol at different temperatures with different ratio. Moreover, to discuss the rationality of anhydrous ethanol as a specific solvent. METHODS Determine the solubility of curcumin in different concentration of lysine solutions at different temperature, and get the thermodynamic constants by calculating. RESULTS The ternary phase diagrams were graphed; K_（sp）, K_（ll）, △G°, △H and △S were calculated. CONCLUSION Anhydrous ethanol could be used as a specific solvent to extract curcumin monomer mixed in curcumin-lysine cocrystal.