肿瘤微环境MMP酶响应性纳米给药系统研究进展

MMP Enzyme in Tumor Micro-environment:A Promising Target for Nano-medicine Delivery

肿瘤靶向纳米制剂的研究是近些年医药领域内的研究热点之一。其中,肿瘤微环境在肿瘤增殖、侵袭和转移中发挥关键性作用,肿瘤微环境响应性纳米制剂的研究日益受到关注。研究发现,以基质金属蛋白酶(matrix metalloproteinase,MMP)为代表的酶类在多种肿瘤微环境中高度表达,其底物可被设计应用于药物传递及成像系统,并显示出了对肿瘤微环境内MMP的高度响应。本文对肿瘤微环境内以MMP为代表的高表达酶为靶点的纳米给药系统的研究进展作一概述。

Recently, plenty of researches have been done on the tumor targeting nano-medicines. As the study on tumor progression, invasion and metastasis deepens, tumor micro-environment responsive nano-preparations become an issue of increasing concern. Enzymes represented by matrix metalloproteinase（MMP） are highly expressed within the tumor micro-environment. Therefore, its substance can be designed for drug delivery and imaging. In this review, nano-delivery system responding to MMP and other highly expressed enzymes are generally introduced.