双歧三联活菌片联合头孢哌酮钠舒巴坦钠对肝硬化并发自发性腹膜炎患者血清中IL-12、IL-18及CRP水平的影响

Effects of microecological preparation combined with cefoperazone sodium sulbactam sodium on serum IL-12,IL-18 and CRP levels in patients with cirrhosis spontaneous peritonitis

目的探讨微生态制剂联合头孢哌酮钠舒巴坦钠对肝硬化并发自发性腹膜炎患者血清中白细胞介素-12(IL-12)、IL-18及C-反应蛋白(CRP)水平的影响。方法选取郑州人民医院2014年5月—2016年7月收治的89例肝硬化并发自发性腹膜炎患者,随机分组,对照组44例,观察组45例,对照组予以单一头孢哌酮钠舒巴坦钠治疗,观察组给予头孢哌酮钠舒巴坦钠加双歧三联活菌片治疗,观察比较两组临床治疗效果及血清IL-12、IL-18、CRP水平,并统计比较两组治疗后并发症发生情况及治疗前后日常生活能力评分。结果观察组治疗总有效率为95.56%(43/45),高于对照组79.55%(35/44),差异具有统计学意义(P<0.05);治疗后观察组IL-12、IL-18及CRP水平均低于对照组,差异具有统计学意义(P<0.05);观察组并发症发生率为8.89%(4/45),对照组为4.55%(2/44),组间对比差异无统计学意义(P>0.05)。结论双歧三联活菌片联合头孢哌酮钠舒巴坦钠治疗可有效改善肝硬化并发自发性腹膜炎患者日常生活能力及炎症因子水平,提高疗效,且安全性高。

Objective To investigate the effects of microecological preparation combined with cefoperazone sodium and sulbactam sodium on serum interleukin-12（ IL-12）,IL-18 and C-reactive protein（ CRP） in patients with cirrhosis spontaneous peritonitis. Methods From May 2014 to July 2016,89 patients with liver cirrhosis complicated with spontaneous peritonitis in Zhengzhou People ＇s Hospital were randomly divided into control group（ n = 44） and observation group（ n = 45）. The control group was treated with single cefoperazone sodium and sulbactam sodium,the observation group was treated with cefoperazone sodium sulbactam sodium ＋ microecological preparation. The clinical treatment effect and serum IL-12,IL-18 and CRP levels of were observed and compared between the two groups. and the incidence of complications after treatment and the daily life ability score before and after treatment were statistically compared. Results The total effective rate in the observation group was 95. 56%（ 43/45）,which was higher than that in the control group（ 79. 55%,35/44）,the difference was statistically significant（ P〈0. 05）; The levels of IL-12,IL-18 and CRP in the observation group were lower than those in the control group after treatment,the difference was statistically significant（ P〈0. 05）; There was no significant difference in the incidence of complications between the observation group 8. 89%（ 4/45） and the control group 4. 55%（ 2/44）（ P〈0. 05）; The daily life ability score of the observation group was higher than that of the control group after treatment,the difference was statistically significant（ P〈0. 05）. Conclusions Microecological preparation combined with cefoperazone sodium and sulbactam sodium can effectively improve the daily living ability and inflammatory factors of patients with cirrhosis spontaneous peritonitis,improve the curative effect and high safety.