加强药物疗法联合鼻内镜手术治疗慢性鼻-鼻窦炎疗效观察

Clinical observation of strengthening drug therapy combined with nasal endoscopic surgery for chronic nasal sinusitis

目的观察加强药物疗法联合鼻内镜手术综合治疗慢性鼻-鼻窦炎患者的临床疗效。方法选取2015年3月至2016年3月在我院接受治疗的慢性鼻-鼻窦炎患者86例,根据随机数表法分为观察组和对照组,每组43例,对照组患者给予加强药物治疗,疗程为12周。观察组则在对照组治疗的基础上加用鼻内镜手术治疗。比较两组患者的临床疗效,治疗前后症状情况、白细胞介素(IL-8)、肿瘤坏死因子-α(TNF-α)水平变化以及躯体症状、精神功能情况。结果观察组患者的治疗总有效率为93.02%,明显高于对照组的76.74%,差异有统计学意义(P<0.05);治疗后观察组和对照组患者的视觉模拟评分(VAS)分别为(1.3±0.3)分、(2.1±0.7)分,均明显低于治疗前,且观察组明显低于对照组,差异均有统计学意义(P<0.05);治疗后观察组患者的IL-8、TNF-α水平分别为(191.2±70.2)μg/L、(34.2±13.1)μg/L,均明显低于对照组的(225.6±82.5)μg/L、(40.5±11.5)μg/L,差异均有统计学意义(均P<0.05);治疗后观察组患者躯体症状及精神功能评分分别为(3.5±1.4)分、(2.2±1.3)分,均显著低于对照组的(7.9±3.1)分、(9.8±4.6)分,差异有统计学意义(均P<0.05)。结论加强药物疗法联合鼻内镜手术综合治疗慢性鼻-鼻窦炎的疗效显著,其可有效改善患者症状,控制炎症反应,同时显著改善其躯体症状及精神功能。

Objective To observe the clinical effects of strengthening drug therapy combined with nasal endoscopic surgery in the treatment of patients with chronic nasal sinusitis. Methods A total of 86 cases of patients with chronic sinusitis, who admitted to our hospital from March 2015 to March 2016, were selected and divided into the ob- servation group and the control group according to random number table method, with 43 cases in each group. The control group were given strengthening drug treatment for 12 weeks. The observation group was treated with additional nasal endoscopic surgery based on the control group＇s treatment. The clinical curative effect, symptoms before and after the treatment situation, interleukin-8 （IL-8）, tumor necrosis factor alpha （TNF-α level changes, physical symptoms and mental function of the two groups were compared. Results The total effective rate of the observation group was 93.02%, which was significantly higher than 76.74% in the control group （P〈0.05）. After the treatment, the Visual Analogue Scale （VAS） of the observation group and the control group were respectively （1.3.4.0.3） points and （2.1±0.7） points, which were significantly lower than those before the treatment, and the observation group was significantly lower than the control group （P〈0.05）; the levels of IL-8 and TNF-α in the observation group were respectively （191.2±70.2） μg/L and （34.2±13.1） μg/L, which were significantly lower than （225.6±82.5）μg/L and （40.5± 11.5） μg/L in the control group （P〈0.05）; the physical symptoms and mental function score in the observation group were respectively （3.5±1.4） points and （2.2±1.3） points, which were significantly lower than （7.9±3.1） and （9.8±4.6） in the control group （P〈0.05）. Conclusion To strengthen the combination of drug therapy with nasal endoscopic surgery has significant curative ef- fect in the treatment of chronic nasal sinusitis, which can effectively improve the symptoms of patients, control the inflammatory response, and significantly improve their physical symptoms and mental function.