5-羟色胺转运体启动子多态与结直肠癌化疗相关性疲乏的易感性

The correlation between 5-HTTLPR and the susceptibility to chemotherapy-related fatigue in colorectal cancer

目的分析5-羟色胺转运体基因启动子多态(5-HTTLPR)长短变体(LL、LS、SS)与结直肠癌化疗相关性疲乏的易感性。方法回顾性分析121例结直肠癌患者的5-HTTLPR基因分型及临床资料。收集患者外周血以及有关临床病理资料。X^2检验分析中到重度结直肠癌化疗相关性疲乏与5-HTTLPR基因分型及各临床病理因素的相关性,logistic多因素风险模型进一步分析5-HTTLPR长短变体对中到重度结直肠癌化疗相关性疲乏的独立影响。结果化疗相关疲乏与5-HTTLPR基因型相关(P=0.025)。Logistic多因素分析显示SS型基因组患者较LL型基因组患者发生中到重度化疗相关性疲乏风险明显增高(OR=8.225,95%CI 1.694~39.927,P=0.009)。结论 5-HTTLPR长短变体SS型基因是发生结直肠癌中到重度化疗相关性疲乏的独立危险因素。

Objective To analyze the correlation between serotonin transporter promoter polymorphism （5 - HT- TLPR） and the susceptibility to chemotherapy - related fatigue in colorectal cancer. Methods The data of 5 - HTTLPR genotypes and clinical data of 121 patients with coloreetal cancer were retrospectively analyzed. The peripheral blood and clinicopathologieal data were collected. The correlations between 5 - HTTLPR genotype and clinical pathological factors were analyzed by chi - square test. Unconditional logistic regression model was used to analyze the association between 5 - HTTLPR variant and colorectal cancer chemotherapy - related fatigue. Results Chi - square test showed that chemo- therapy - related fatigue was associated with 5 - HTTLPR genotype （ P = 0. 025 ）. Unconditional logistic regression model showed that patients with genotype SS had a significantly higher risk of moderate to severe chemotherapy - related fatigue （ OR = 8. 225, 95 % CI 1. 694 - 39. 927, P = 0. 009） than genotype LL. Conclusion The genotype SS of 5 - HTTLPR variant is an independent risk factor for moderate to severe chemotherapy -related fatigue in colorectal cancer.