《黄帝素问宣明论方》用药数据分析

Analysis on composition principles in the Huangdi Suwen Xuanming Lunfang of LIU Wansu based on data mining

目的对刘完素《黄帝素问宣明论方》进行数据挖掘,以寻找刘完素重视脾胃用药的证据,完善其学术体系。方法利用统计学和数据挖掘的方法,共收集《黄帝素问宣明论方》中的方剂195首。利用excel软件建立刘完素方药数据库,在Windows 7平台采用SPSS 17.0和clementine 12.0软件对数据进行描述性分析、关联规则分析和聚类分析。结果使用频率最高的前5位中药依次为炙甘草、白术、人参、茯苓、大黄;经过关联规则分析,共得到关联规则46组;经过聚类分析共得到核心药物组合10组,其中9味入脾胃经。结论刘完素临床用药最重视健脾养胃,并非都用寒凉药。这对后人全面掌握刘完素的学术思想,以及临床用药都具有指导意义。

Objective Through data mining on the Huangdi Suwen Xuanming Lunfang of LIU Wansu,to find evidence of LIU Wansu ＇s attention to the data evidence of the spleen and stomach drugs,and improve LIU Wansu＇s academic system. Methods A total of 195 prescriptions were included in the prescription by using the method of statistics and data mining. The database was established by using Excel software,using SPSS17. 0 and clementine12. 0 software for data analysis,association analysis and clustering analysis on Windows 7 platform. Results The top five traditional Chinese medicine with the highest frequency were Zhigancao,Baizhu,Renshen,Fuling and Daluang. There were 11 pairs of core Chinese medicine combination were figured out by cluster analysis. The association rules of 46 groups were obtained. Conclusion LIU Wansu attaches great importance to strengthen the spleen and stomach in clinic,which indicates he doesn＇t always use cold medicines. This study is meaningful for us to fully grasp LIU Wansu＇s academic thoughts and clinical medication.