老龄人群甲状腺功能与身体成分的相关性分析

Correlation between thyroid function and body composition in the elderly with euthyroid gland

目的 :探索老龄人群中甲状腺激素与肌肉及脂肪等身体成分的内在联系。方法 :74例年龄≥60岁的甲状腺功能正常的健康体检者,平均年龄(74.6±7.7)岁,测定其体重、甲状腺功能及身体成分等。结果:游离三碘甲状腺原氨酸(free triiodothyronine,FT3)与四肢肌肉质量(appendicular muscle mass,ASM)呈正相关(P=0.003),校正年龄、性别及体重指数(body mass index,BMI)后二者间仍存在正相关性(P=0.011);FT3与总肌肉量(去除头部)呈正相关(P=0.024),校正年龄、性别及BMI后仅发现女性入组者中二者仍呈正相关,而男性中未见明显相关;促甲状腺激素(thyroid stimulating hormone,TSH)与四肢脂肪含量、总脂肪量(去除头部)呈负相关(P=0.039;P=0.038),校正混杂因素后并未发现明显相关性。结论:甲状腺功能正常的老龄人群中甲状腺激素水平影响身体成分。

Objective： This study is aimed to explore the relationship between thyroid hormone and body composition in the elderly with euthyroid gland. Methods： Seventy-four euthyroid subjects with an average age 74.6±7.7 years old have been involved. Body weight, thyroid function and body composition have been measured. Results： Appendicular muscle mass （ASM） was positively associated with FF3 （P=0.003）. There is still a positive correlation between the two indexes after adjusting for age, sex and body mass index （BMI） （P=0.011）. FT3 was positively correlated with lean subtotal（P=O.024）. We found the same correlation between ASW and FT3 in female （P=-0.043）, but not male, after adjusting for age, sex and BMI.TSH was negatively correlated with appendicular fat mass and fat subtotal（P=0.039; P=-0.038）.None correlation between the two has been found after adjusting for confounding factors. Conclusion：Thyroid hormone is related with body composition in the elderly with euthyroid gland.