宫颈癌组织中Ezrin蛋白及CD44v6蛋白表达的临床意义

Clinical significance of Ezrin protein and CD44v6 protein expressions in cervical cancer tissues

目的探讨宫颈癌组织中埃兹(Ezrin)蛋白及CD44v6蛋白表达的临床意义。方法应用免疫组织化学SP法检测2008年10月至2015年10月河南省郑州市第三人民医院经手术证实的50例宫颈癌组织、36例宫颈上皮内瘤变(CIN)组织和28例正常宫颈组织中Ezrin蛋白及CD44v6蛋白的表达,结合其表达情况及临床资料进行统计学分析。结果宫颈癌、CIN和正常宫颈组织中Ezrin蛋白表达阳性率分别为84.00%、61.11%、35.71%,CD44v6蛋白表达阳性率分别为68.00%、41.67%、25.00%,不同类型宫颈组织Ezrin蛋白、CD44v6蛋白表达阳性率比较,差异均有统计学意义(P<0.05)。Ezrin蛋白和CD44v6蛋白表达与宫颈癌组织分化程度和淋巴结转移有关,与组织学类型和临床分期无关。结论 Ezrin蛋白和CD44v6蛋白共同参与了宫颈癌侵袭、转移,联合检测2项指标有助于对宫颈癌患者预后的评估。

Objective To investigate the expression and significance of Ezrin and CD44v6 proteins in cervical cancer tissues. Methods The expression of Ezrin and CD44v6 proteins were detected by immunohistochemistry in 50 cases of cervical cancer tissue, 36 cases of intraepithelial neoplasia （CIN） tissue and ：28 cases of normal cervical tissue verified by operation in the Zhengzhou Municipal Third People＇s Hospital from October 2008 to October 2015. Their expressions situation combining with clinical data were statistically analyzed. Results The positive expression rate of Ezrin and CD44v6 proteins in cervical cancer, CIN and normal cervical tissues were 84.00%, 61.11%, 35.71% and 68.00% ,41.67% , 25.00% respectively, the positive expres sion rate of Ezrin and CD44v6 proteins had statistical differences among different types of cervical tissue （P〈0.05）. Ezrin and CD44v6 proteins expression were related with cervical cancer tissue differentiation degree and lymph node metastasis, and had no relation with the histological type and clinical stage. Conclusion Ezrin and CD44v6 proteins jointly participate in the invasion and metastasis of cervical cancer. The combined detection of Ezrin and CD44v6 proteins conduces to evaluate the prognosis in the patients with cervical cancer.