Progranulin在糖脂代谢及肾脏疾病调控机制中的研究进展

Progranulin in Regulation Mechanism of Glycolipid Metabolism and Renal Disease

颗粒体上皮蛋白前体(PGRN)广泛分布于上皮细胞、免疫细胞、神经细胞等多种细胞中,具有多种功能。完整形式的PGRN可通过与肿瘤坏死因子α(TNF-α)结合,进而抑制TNF-α/TNF受体通路来发挥抗炎作用,而经蛋白酶加工后的PGRN通过增加促炎因子的产生而具有促炎效应。PGRN可作为抗炎因子参与早期胚胎发育和组织重塑,还可通过抑制炎症、促进自噬在肾脏疾病发生发展过程中发挥重要作用,此外,PGRN也可作为脂肪细胞因子参与肥胖和胰岛素抵抗等过程,参与肥胖和糖尿病的发生。

Progranulin（ PGRN） is a multifunctional molecule expressed widely in epithelial cells,immune cells,neurons and so on. Intact PGRN can bind to tumor necrosis factor（ TNF） α,impairing the TNF-α/TNF receptor interaction and suppressing inflammation process,while after being cleaved into granulins by proteases,it can increase the production of proinflammatory cytokines to show proinflammatory feature. In early embryogenesis and tissue remodeling,PGRN acts as an anti-inflammatory molecule. In renal disease,PGRN shows its anti-inflammatory and autophagy promoting effect. It also acts as an adipokine involved in obesity and insulin resistance of diabetes.