影响糖尿病患者维生素B_(12)水平的主要因素及机制

Main Factors and Mechanisms Influencing Vitamin B_(12) Level in Patients with Diabetes Mellitus

维生素B_(12)在人体内具有多种重要的生理功能,其缺乏会引起相应的症状。维生素B_(12)水平的界定及其检测指标,对评估糖尿病患者血清维生素B_(12)具有重要意义。无论是1型糖尿病还是2型糖尿病患者均存在维生素B_(12)缺乏的风险。而影响糖尿病患者维生素B_(12)水平的因素有多种,包括年龄、肾功能、糖尿病代谢异常及应用二甲双胍等,每个因素通过不同的机制对维生素B_(12)产生影响。目前,对于糖尿病患者缺乏维生素B_(12)的预防及治疗措施尚无定论。今后,应更加重视糖尿病患者的维生素B_(12)水平监测和外源性补充。

Vitamin B_（12） plays pivotal roles in multiple physiological functions in human body,the lack of which will cause corresponding symptoms. The definition and detection index of vitamin B_（12） level is important for estimating serum vitamin B_（12） in diabetic patients. In fact,both type 1 and type 2 diabetic patients have the risk of being deficient in vitamin B_（12）.There are a variety of factors affecting the level of vitamin B_（12） in patients with diabetes,including age,renal function,metabolic disorders of diabetes,and the use of metformin,through different mechanisms. At present,there is still no conclusion how to prevent and treat the vitamin B_（12） deficiency. In the future,more attention should be paid to vitamin B_（12） levels and exogenous supplementation in patients with diabetes.