补中益气汤对癌因性疲乏的影响

Effects of Buzhong Yiqi Decoction on cancer-related fatigue

目的研究补中益气汤对癌因性疲乏的影响。方法将我院收治的60例癌因性疲乏病例随机分为对照组(n=30,化疗)和实验组(n=30,化疗联合补中益气汤),比较两组治疗前后生活质量、疲乏改善情况及不良反应出现率。结果治疗后两组生活质量评分项目中的社会功能评分对比差异无统计学意义(P>0.05),实验组其他生活质量评分(躯体功能、心理功能、物质生活评分)、生活质量总评分和轻度疲乏率均显著高于对照组(P<0.05或P<0.01),重度疲乏率和消化道不良反应发生率明显低于对照组(P<0.05或P<0.01);骨髓抑制反应出现率两组比较差异无统计学意义(P>0.05)。结论补中益气汤可显著改善癌因性疲乏患者疲乏程度,减少消化系统不良反应,提高生活质量。

Objective To Sixty patients with cancer-re study the effects of Buzhong Yiqi Decoction on cancer-related fatigue. lated fatigue who were admitted to our hospital were enrolled in the Methods study and were randomly divided into a control group （n =30, chemotherapy） and an experimental group （n=30, chemotherapy combined with Buzhong Yiqi Decoction）. Quality of life, relief of fatigue and incidence of adverse reactions were compared between the two groups before and after treatment. Results Comparison of the post-treatment social function score among scores of General Quality of Life Inventory between the experimental group and the control group yielded no significant difference （ P 〉 0. 05）, and in the experimental group, the other quality of life scores （including body function, psychological function and material life scores）, the total quality life of scores and mild fatigue rate were significantly higher than those in the control group （ P〈0.05 or P〈0.01）, the occurrence of severe fatigue rate and adverse reaction rate of gastrointestinal tract were significantly less than those of the control group （ P〈0.05 or P〈0.01） ; compared the incidence of bone marrow suppression showed no significant difference between the two groups （ P〉0.05）. Conclusion Buzhong Yiqi Decoction for the treatment of patients with cancer-related fatigue can relieve fatigue, can reduce gastrointestinal adverse reactions, and can improve the patients quality significantly of life.