眼部三氯氧磷中毒致双眼不能下转1例

One Case of Downward Paralysis of the Eyeball Induced by Ocular Phosphorus Oxychloride

通过观察1例双眼三氯氧磷中毒后致双眼下转不能的患者,将其作为首次报道,证实三氯氧磷中毒可影响骨骼肌运动。应注意三氯氧磷除导致肺水肿和化学烧伤等症状外,还可致血胆碱脂酶活性下降。研究发现三氯氧磷水解中间产物二氯化磷酸可抑制胆碱脂酶活性。三氯氧磷中毒可使用阿托品治疗,解磷定不能逆转三氯氧磷对胆碱脂酶的抑制。

The primary report of 1 case with two eyes who were unable to turn down after phosphorus oxychloride poisoning was reported. The case confirms the presumption that phosphorus oxychloride can affect skeletal muscle movement. One should pay attention to the decrease of serum cholinesterase activity induced byphosphorus oxychloride in addition to the symptom of pulmonary edema, chemical burnsect. Human studies have found that phosphorodichloridic acid which is a hydrolysis intermediate product of phosphorus oxychloride can inhibit cholinesterase activity. Atropine can be used to treat the poisoning of phosphorus oxychloride, and pyridine-2-aldoxime methiodide does not reactivate phosphorus oxychloride-inhibited acetylcholinesterase.