SEPT9基因甲基化在结直肠癌诊断中的研究进展

Advances in Study on SEPT9 Gene Methylation in Diagnosis of Colorectal Cancer

结直肠癌(CRC)是最常见的消化道恶性肿瘤之一,其预后差,病死率高。SEPT9基因是一种抑癌基因,在细胞分裂末期起重要作用,目前研究已发现SEPT9基因甲基化检测可用于CRC的早期诊断。本文就SEPT9基因甲基化在CRC筛查和诊断中的研究进展作一综述。

Colorectal cancer（ CRC） is one of the most common gastrointestinal malignancies with poor prognosis and high mortality. SEPT9 gene is a tumor suppressor gene and plays an important role in the end of cell division. Studies have shown that methylation of SEPT9 gene could be used in the early diagnosis of CRC. This article reviewed the advances in study on SEPT9 gene methylation in the screening and diagnosis of CRC.