自拟清血消白方联合西医对微小病变型肾病综合征蛋白尿和血脂的研究

Self Qingxue XiaoBai Fang (SQXF) combined with Western medicine in treatment of minimal change nephrotic syndrome and its effect on proteinuria and blood lipids

目的探讨自拟清血消白方联合西医治疗微小病变型肾病综合征的临床疗效。方法将2012年1月至2015年6月病理资料证实且首诊为微小病变型肾病综合征的100例患者,将患者随机分为对照组和观察组,各50例。对照组患者采用单纯常规西医治疗,观察组在对照组的治疗基础上联合应用自拟清血消白方。比较2组患者的临床治疗效果及蛋白尿和血脂水平变化。结果观察组患者有效率为90.00%,与对照组(70.00%)比较明显增加,差异有统计学意义(χ~2=9.22,P<0.05)。观察组患者治疗后24h尿蛋白定量[(0.52±0.10)g]、三酰甘油[(0.83±0.18)mmol/L]、胆固醇[(4.31±0.94)mmol/L]、肌酐[(120.11±10.12)μmol/L]、尿素氮[(4.02±0.77)mmol/L]与治疗前比较明显减少(t=7.66,7.38,7.91,8.55,7.72,P<0.05),清蛋白[(39.65±3.32)g/L]与治疗前比较明显增加(t=7.20,P<0.05),且各项指标与对照组比较,差异均有统计学意义(t=7.21,6.65,7.51,7.81,6.98,6.88,P<0.05)。结论自拟清血消白方联合西医治疗微小病变型肾病综合征临床效果明显,能显著改善患者肾功能和血脂水平,具有临床应用和推广价值。

Objective To explore the clinical efficacy of SQXF combined with western medicine and its impact of minimal change nephrotic syndrome in patients with proteinuria and serum lipid. Methods 100 patients diagnosed with minimal change nephrotic syndrome were chosen for the study in Shijiazhuang Nephropathy Hospital of Hebei Province from January 2012 to June 2015,50 patients were treated with conventional Western medicine alone,while the observation group of 50 patients at the same time com- bined with SQXF. Clinical effect and impact on patients proteinuria and serum lipid levels were analysed. Results The effective rate of the observation group was 90.00 % and markedly higher than 70.00 %of the control group, the difference was significant（z2 ： 9.22, P〈0.05）. 24 h urinary protein（0.52± 0.10）g of the observation group after treatment, triglycerides（0.83±0.18）mmol/L, cholesterol（4.31± 0.94）mmol/L, serum creatinine（ 120.11± 10.12） μmol/L, blood urea nitrogen（4.02 ±0.77） retool/L, were sig- nificantly decreased than pre-treatment （t = 7.66,7.38,7.91,8.55,7.72, P〈 0.05 ）, serum albumin （ 39.65 ± 3.32） g/L were signifi- cantly increased than pre-treatment（t = 7. 20, P〈 0.05）, and were significantly different compared with control group （t =7.21, 6.65,7.51,7.81,6.98,6.88, P〈 0.05）. Conclusion SQXF combined with Western medicine in treatment of minimal change ne phrotic syndrome has obvious advantages, and it can significantly improve renal function and blood lipid levels, clinical application and promotion of great value.