苦碟子联合西药治疗椎基底动脉供血不足性眩晕的临床研究

The clinical study of heris sonchifolia Hance combined with western medicine in the treatment of vertigo caused by vertebrobasilar ischemia

目的分析苦碟子联合西药治疗椎基底动脉供血不足性眩晕的临床研究。方法80例椎基底动脉供血不足性眩晕患者随机分为研究组和对照组，每组40例。对照组给予丁苯酞氯化钠治疗，研究组在对照组基础上结合苦碟子治疗，两组患者均以10d为治疗疗程。对比两组治疗总有效率，治疗前后椎动脉（VA）与基底动脉（BA）的舒张末期血流速度（vd）、收缩峰血流速度（Vp）变化和血液流变学变化及不良反应情况。结果治疗总有效率研究组高于对照组（92．50％比67．50％），两组比较差异有统计学意义（P〈0．05）；两组VA与BA的Vd、Vp治疗后较治疗前增加（P〈0．05）；研究组vA与BA的Vd、Vp治疗后高于对照组（P〈0．05）；两组全血黏度低切、全血黏度高切、血浆黏度及纤维蛋白原治疗后较治疗前降低（P〈0．05）；研究组全血黏度低切、全血黏度高切、血浆黏度及纤维蛋白原治疗后低于对照组（P〈0．05）；两组用药期间均未发生明显不良反应。结论苦碟子联合西药治疗椎基底动脉供血不足性眩晕的临床明显，具有重要研究价值。

Objective To analyze the clinical effect of Ixeris sonchifolia Hance combined with western medicine in the treatment of vertigo caused by vertebrobasilar ischemia （VBI）. Methods 80 cases of vertigo caused by vertebrobasilar ischemia were randomly divided into research group （n=40） and control group （n=40）. The control group was treated with butyphthalide sodium chloride, the research group was treated with Ixeris sonchifolia Hance on the basis of the treatment in the control group. Both groups were treated for 10 d. Compared the total effective rate, the changes of Vd and VP in vertebral artery （VA） and basilar artery （BA） before and after treatment, the change of hemorheology, and adverse reactions in both groups. Results The total effective rate of the research group was higher than that of the control group （92.50% vs.67.50%）, with statistically significant difference （P〈0.05）. Vd and VP in VA and BA in the two groups significantly increased after treatment （P〈0.05）, Vd and VP in VA and BA in the research group were higher than those in the control group after treatment （P〈0.05）. Low shear viscosity, high shear viscosity, plasmic viscosity, and fibrinogen in the two groups significantly decreased after treatment （P〈0.05）, low shear viscosity, high shear viscosity, plasmic viscosity, and fibrinogen in the research group were lower than those in the control group after treatment （P〈0.05）. There were no obvious adverse reactions during the treatment course. Conclusion Ixeris sonchifolia Hance combined with western medicine in the treatment of vertigo caused by vertebrobasilar ischemia has significant clinical effect, of great significance.