病毒感染激活TLRs和RLRs介导的IFN信号通路研究进展

Progress on IFN Signaling Pathways Mediated by Virus Infection Activated TLRs and RLRs

在病毒侵染机体的过程中,机体的多数组织器官可以高效产生干扰素。近些年的研究发现,能够有效识别病毒侵染机体过程中的相关模式分子(例如病毒复制中间产物双链RNA)的细胞受体是产生干扰素的主要感受器,这些细胞受体(例如Toll样受体和RIG-Ⅰ样受体)能够诱发一系列的信号级联反应,并且被激活的感受器可以启动干扰素相关基因的转录活性,从而产生特定的干扰素。值得注意的是,不同种类的病毒能够倾向性地去激活特定的细胞感受器,并且产生特定的信号转导通路。论文主要从Toll样受体和RIG-Ⅰ样受体的结构入手,讨论宿主细胞模式受体在干扰素抗病毒过程中行使的功能,并简单介绍干扰素在抗病毒过程中的信号级联反应。

During the course of infection by viruses,the protein,namely interferon （IFN）, can be efficiently generated by various tissues and organs of host.Recently, many studies focused on how the middle products （i.e double strand RNA from virus＇ replication） stimulate sensors which are cell surface receptors（such as Toll-like receptors and RIG-Ⅰ like receptors ）,inducing a series of signal cascades and initiating the transcription of interferon-related genes in order to generate IFN. Of note, the specific type of virus have a strong tendency to initiate the specific cell＇s sensors and generate the specific signal pathway.In this article, the process of antiviral function was discussed, and the interferon signaling cascade in the process of antiviral response was introduced from the structure of Toll-like receptors and RIG-Ⅰ like receptors of host cell receptors .