动态脑电图在判断癫癎患者能否停药中的应用

APPLICATION OF AMBULATORY ELECTROENCEPHALOGRAM IN JUDGING WHETHER PATIENTS WITH EPILEPSY CAN DISCONTINUE DRUGS

目的:探讨动态脑电图(AEEG)在判断癫癎患者能否停药中的应用价值。方法:对我院经过正规抗癫癎治疗,临床停止发作3年以上的75例癫癎患者,进行了3年AEEG随访,随访过程中每年行AEEG复查至少1~2次,复查过程中只要此患者AEEG有放电,有1次异常,则此患者即为异常,据此观察75例癫癎患者不同年限段AEEG的异常率。结果:75例癫癎患者临床停止发作3年后行AEEG随访3年的异常率分别为:第1年36.0%、第2年24.0%、第3年18.7%。其中AEEG检测3年均未见异常的38例;每次均异常的5例;正常异常交替出现的32例。结论:癫癎患者经正规治疗临床停止发作3年以上,随访3年AEEG未见异常者可考虑缓慢减药、停药;AEEG检测每次均异常者不可减药、停药;AEEG正常、异常交替出现者待AEEG连续正常3年后再减药、停药比较稳妥。

Objective： To explore the applied value of ambulatory electroencephalogram （AEEG） in judging whether patients with epilepsy can discontinue drugs. Methods： Seventy-five patients with epilepsy who had received regular anti-epileptic treatment and ceased epileptic seizure for over 3 years, were followed up for 3 years with AEEG. During the process of follow-up, AEEG was performed at least 1-2 times every year, in which as long as the abnormal discharge was showed, it was abnormal. The abnormal rate of AEEG in 75 patients with epilepsy was recorded during the period of 3 years respectively. Results： The abnormal rate of AEEG was 36.0% in the first year, 24.0% in the second year, and 18.7% in the third year. During 3 years follow- up, there were 38 patients who had a normal AEEG all the time, 5 who had an abnormal AEEG all the time, and 32 who had a normal and abnormal AEEG alternately. Conclusions： The patients had a normal AEEG all the time during the 3 years of follow-up can consider gradually reducing or even discontinuing drugs, the patients who had an abnormal AEEG all the time should not reduce or discontinue drugs; while those who had a normal and abnormal AEEG alternately are suggested to reduce or discontinue drugs upon their AEEG being normal for three consecutive years.