曲美他嗪联合阿托伐他汀对冠心病患者血脂及心功能的影响

Effects of trimetazidine combined atorvastatin on blood lipids and cardiac function of the patients with coronary heart disease

目的探讨曲美他嗪联合阿托伐他汀对冠心病患者血脂、心功能的影响。方法将178例冠心病患者按随机数字法分为2组,每组89例。对照组给予阿托伐他汀,观察组在此基础上加用曲美他嗪组。治疗后,比较两组血脂[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、心绞痛情况(发作次数、每次持续时间)、心功能[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]、不良反应情况。结果治疗后,两组TC、TG、LDL-C水平显著改善(P<0.05),且观察组TC、TG、LDL-C水平显著低于对照组(P<0.05)。治疗后,两组心绞痛发作次数、每次持续时间均显著减少(P<0.05),且观察组心绞痛发作次数、每次持续时间显著低于对照组(P<0.05)。治疗后,观察组LVEDD、LVESD水平显著低于对照组(P<0.05),而观察组LVEF水平显著高于对照组(P<0.05)。结论曲美他嗪联合阿托伐他汀可有效改善冠心病患者血脂和心功能。

Objective To investigate the effects of trimetazidine combined atorvastatin on blood lipid and car- diac function in patients with coronary heart disease. Methods 178 patients with CHD were divided into 2 groups ac- cording to random number method, namely control group and observation group. Patients in control group were given ator- vastatin,and patients in observation group were added trimetazidine on the basis of control group. The blood lipid[ Total cholesterol （TC） ,Triacylglycerol （TG）, High density lipoprotein cholesterol （HDL-C）, Low density lipoprotein choles- terol （LDL-C）], angina pectoris （ attack frequency, duration）, cardiac function E Left ventricular end diastolic diameter （LVEDD） , Left ventricular end-systolic diameter （ LVESD）, Left ventricular ejection fraction （LVEF） ] and adverse e- vents of two groups were compared after treatment. Results After the treatment, serum TC, TG and LDL-C levels of two groups were significantly improved （P 〈 0.05 ）. TC, TG and LDL-C levels of observation group were significantly lower than those of control group （ P 〈 O. 05 ）. After the treatment, the angina pectoris attack times and duration time of two groups were significantly decreased （ P 〈 0.05 ）, and angina pectoris attack times and duration time of observation group were significantly lower than those of control group （ P 〈 0.05 ）. After the treatment, LVEDD and LVESD levels of obser- vation group were significantly lower than those of control group （ P 〈 0.05） , and LVEF level of observation group was significantly higher than that of control group （ P 〈 0.05 ）. Conclusion Trimetazidine combined atorvastatin could ef- fectively improve the blood lipid and cardiac function of the patients with coronary heart disease.