血尿酸与其他代谢指标的相关性研究

Clinical study on the correlation between serum uric acid and other metabolic indexes

目的探讨影响血尿酸(UA)的相关代谢指标。方法选取符合纳入标准的10 000名体检者作为研究对象。采集受试者收缩压(SBP)、舒张压(DBP),血清UA、血脂相关指标[包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)]、糖化血红蛋白(Hb A1c)、空腹血糖(FBG)。按照性别和UA分组,分析血UA与其他代谢指标的相关性。结果 (1)高尿酸血症(HUA)检出率为26.2%,男性检出率为25.1%,女性检出率为32.4%,性别比较,差异有统计学意义(P<0.05);(2)男女之间年龄、Hb A1c、TC、TG和LDL-C等指标比较,差异无统计学意义(P>0.05),女性BMI、FBG、SBP、HDL-C和DBP高于男性,男性血UA水平高于女性(P<0.05);(3)女性HUA患者年龄、体质量指数(BMI)、SBP、DBP、FBG和TG高于尿酸正常组(NUA组),HDL-C低于HUA组;男性HUA年龄、BMI、SBP、DBP和TG高于NUA组,而HDL-C低于NUA组(P<0.05)。女性UA水平与年龄、BMI、SBP、DBP、FBG、TC、TG水平呈正相关;男性UA与年龄、BMI、SBP、DBP、TC、TG水平呈正相关(P<0.05);血尿酸水平与HDL-C呈负相关(P<0.05)。结论性别、BMI、血压、血糖、TG及TC、LDL-C和HDL-C与HUA的发生有关。

Objective To explore the relevant factors of HUA, and improve the prevention and treatment of HUA. Method 10 000 subjects were selected as the object of study from physical examination. Clinic data, SBP, DBP, UA,TC,TG,LDL-C and HDL-C,HbAIc and FBG were collected. Results （1）Among the 10,000 subjects,of which women were 1492 （ 14.92% ） and men were 8508 （85.08%）. The prevalence of hyperuricemia was 26.2% （25.1% for males and 32.4% for females）. （2） There were not statistically significant in age, HbA, c, Tc, TG and LDL-C between men and women, but BMI, FBG, SBP, DBP, HDL-C in women were higher thanthose in men,while the uric acid level in men was higher than that in women, the difference was statistically significant. （3）The age, BMI, SBP, DBP, FBG, and TG of women with hyperuricemia were higher than those without the disease, while HDL-C was lower than that of patients with UA. The age,TG higher than those who did not suffer from this disease, HDL-C was lower than those who did not suffer the disease,the difference was statistically significant. （4） The level of female serum uric acid was posi- tively correlated with age, BMI, SBP, DBP, DBP, FBG, TC, TG level （ P 〈 0.05 ）. The levels of male UA were positively correlated with age, BMI, SBP, DBP, TC, and HDL-C was negatively correlated （ P 〈 0.05 ）. Conclusion Gender, BMI, blood pressure, blood glucose,TG and TC, LDL-C, HDL-C are related to the occurrence and development of HUA.