微小核糖核酸在骨关节炎中的研究进展

Research progress of microRNAs in osteoarthritis

骨关节炎(OA)是一种随年龄增长而发生率上升的以关节软骨退变和关节周围骨质增生为病理特征的慢性进行性骨关节疾病,同时软骨细胞表型和软骨内稳态的变化以及软骨下骨的代谢变化是骨关节炎发展过程中密不可分的一部分。微小RNA(microRNA或miRNA)属于内源性非编码蛋白的单链小分子RNA,主要通过调控基因转录后水平,进而对组织生长和稳态进行控制。本文基于miRNA的基因调控机制,从其生物学特性、miRNA与软骨形成及关节软骨、miRNA与疼痛及炎性反应等几个方面对两者关系进行综述,为临床治疗提供新的策略。

Osteoarthritis （OA） is a chronic progressive osteoarthrosis characterized by articular cartilage degen- eration and peri -articular bone hyperplasia, which is associated with an increase in age. Chondrocyte phenotype, carti- lage changes in the steady state and subchondral bone metabolism are the inseparable part of the development of osteoar- thritis. MicroRNA belongs to the endogenous non - coding protein of single-stranded small RNA, mainly through the reg- ulation of gene transcription level, and then control tissue growth and steady state. Based on the miRNA gene regulation mechanism, this paper reviews the relationship between miRNA and articular cartilage, miRNA and pain, miRNA and in- flammatory response ,then provides a new strategy for clinical treatment.