创伤性脑外伤与骨折愈合关系的研究进展

Research progress of correlation between traumatic brain injury and fracture healing

目的总结创伤性脑外伤(traumatic brain injury,TBI)对骨折愈合影响机制研究的进展。方法广泛查阅国内外有关TBI对骨折愈合影响的文献,并进行总结分析。结果 TBI影响骨折愈合机制复杂,研究方向可大致分为骨折愈合过程中血管生成及骨再生的调节,以及脑外伤后神经肽及相关激素反应后的局部和全身变化。结论 TBI对骨折愈合起促进作用,其确切作用机制有待进一步研究。

Objective To review the current status and advances of the correlation between traumatic brain injury （TBI） and fracture healing. Methods The related domestic and abroad literature about the correlation between TBI and fracture healing was extensively reviewed and analyzed. Results There are a variety of studies on the correlation between TBI and fracture healing, which can be divided into two major aspects： revascularization and osteogenesis; the local and systemic changes of the neuropeptide and hormone after TBI. Conclusion TBI facilitates callus formation, the further research is needed to clarify the exact mechanism.