白金颗粒对盆腔炎性疾病后遗症模型大鼠的药效学

Pharmacodynamics of Baijin Granules on model rats with sequelae of pelvic inflammatory disease

目的研究壮药白金颗粒(白背叶根和金刚刺)对盆腔炎性疾病后遗症模型大鼠的药效学。方法用大肠杆菌和金黄色葡萄球菌的混合菌加机械损伤法建立盆腔炎性疾病后遗症大鼠模型,随机分为模型组,白金颗粒高、中、低剂量组,阳性对照组(地塞米松片、花红颗粒),空白对照组及假手术组8组,每组10只大鼠。连续给药14 d后,于末次给药24 h大鼠腹主动脉取血,检测血液流变学、血常规,观察子宫组织病理形态。结果模型大鼠的血液流变学指标及白细胞数、中性粒细胞百分比显著降低,子宫组织病理形态显著改善。结论白金颗粒对大鼠盆腔炎性疾病后遗症有较好的治疗作用。

AIM To study the pharmacodynamics of Baijin Granules [ Mallotus apelta （lour.） Muell. Arg. , Smilax china L. ], Zhuang medicine, on model rats with sequelae of pelvic inflammatory disease. METHODS The rat model for sequelae of pelvic inflammatory disease was built with mixed bacteria （Escherichia coli and Staphylococcus aureus） and mechanical injury. Subsequently, the rats were randomly divided into eight groups, in- cluding model, Baijin Granules low-, middle-, high-dose, positive control （dexamethasone and Huahong Gran- ules）, blank control and sham operation groups, with ten rats in each group. After 14 days of successive adminis- tration, the hemorheology and blood routine in rats＇ abdominal aorta were measured by collecting blood in 24 hours of last administration. The pathological morphology of uterine tissue was observed. RESULTS The hemorheology indexes, WBC count and neutrophil percentage were significantly decreased in the model rats, and the pathological morphology of uterine tissue was markedly improved. CONCLUSION Baijin Granules have good therapeutic effects on sequelae of pelvic inflammatory disease in rats.