地西他滨联合预激方案治疗老年骨髓增生异常综合征的临床效果分析

Clinical effect analysis of Decitabine combined with pre-excitation regimen in the treatment of senile myelodysplastic syndrome

目的探讨地西他滨联合预激方案治疗老年骨髓增生异常综合征的临床效果。方法选择2012年6月~2017年1月本院收治的55例老年骨髓增生异常综合征患者作为研究对象,并对所有患者进行数字编号和随机分组,分为两组,对照组30例,观察组25例。对照组患者采用预激方案治疗,观察组采用地西他滨联合预激方案治疗。比较两组患者治疗后的临床效果。结果观察组患者的总有效率(96.00%)显著高于对照组(66.67%),观察组患者的治疗效果更好(P<0.05)。观察组患者肝功能受损、血小板降低、粒细胞减少的不良反应发生率显著低于对照组(P<0.05)。结论地西他滨联合预激方案治疗老年骨髓增生异常综合征具有明显的效果,有利于消除患者的临床症状,促使其尽快恢复,具有重要的临床价值。

Objective To evaluate the clinical effect of Decitabine combined with pre-excitation regimen in the treatment of senile myelodysplastic syndrome.Methods 55 elderly patients with myelodysplastic syndrome who were admit- ted into our hospital from June 2012 to January 2017 were selected as the study objects.All patients were numbered and randomly divided into two groups,and there were 30 patients in the control group,and 25 patients in the observation group.The patients in the control group were given pre-excitation regimen,while the observation group was given Decitabine combined with pre-excitation regimen.The clinical efficacy of patients between the two groups after treat- ment were compared.Results The total effective rate was 96.00% in the observation group,which was significantly high- er than that in the control group （66.67%） and the observation group had a better curative effect （P〈0.05）.The incidence of adverse reactions such as impaired liver function,thrombocytopenia and granulocytopenia in the observation group was significantly lower than those in the control group （P〈0.05）.Conclusion Clinical effect of Decitabine combined with pre-excitation regimen in the treatment of senile myelodysplastic syndrome has a significant effect,which is helpful to eliminate the clinical symptoms of patients and promote the recovery of patients as soon as possible,and has an impor- tant clinical value.